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Characterization of synaptic proteome [Neuroscience]

PNAS Early Edition Articles - Tue, 10/28/2014 - 09:02
Little is known regarding the identity of the population of proteins that are transported and localized to synapses. Here we describe a new approach that involves the isolation and systematic proteomic characterization of molecular motor kinesins to identify the populations of proteins transported to synapses. We used this approach to...

Leak at Metropolis contained by sprays

World Nuclear News - Tue, 10/28/2014 - 06:13
Honeywell's uranium conversion plant at Metropolis, Illinois suffered a leak late on 26 October which plant operators said was contained by prompt action and water sprays.

University freaks about skeptical scientist’s talk on campus: Declare talk to be ‘disservice’; ‘potentially harmful’; ‘unfortunate’ – Lament there was not a panel of 4 or 5 warmists to rebut him

Climate Depot - Mon, 10/27/2014 - 23:45
Fath was at the lecture Thursday night and was one of a handful of TU faculty who challenged what Legates was saying at the end of his talk. Legates shared data and other evidence that, according to him, show that the scientific community is wrong and misguided about anthropogenic climate change. “My concern is that [...]

It’s Official — Temperature ‘Pause’ Caused By Climate Policies?! Medieval witchcraft lives! UK Energy Minister: Government policies ‘may have slowed down global warming’

Climate Depot - Mon, 10/27/2014 - 19:04

Boron-rich liposomes for BNCT in oral cancer [Medical Sciences]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
The application of boron neutron capture therapy (BNCT) mediated by liposomes containing 10B-enriched polyhedral borane and carborane derivatives for the treatment of head and neck cancer in the hamster cheek pouch oral cancer model is presented. These liposomes are composed of an equimolar ratio of cholesterol and 1,2-distearoyl-sn-glycero-3-phosphocholine, incorporating K[nido-7-CH3(CH2)15-7,8-C2B9H11]...

Nanotopography modulates neuronal cell interaction [Applied Physical Sciences]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Extracellular soluble signals are known to play a critical role in maintaining neuronal function and homeostasis in the CNS. However, the CNS is also composed of extracellular matrix macromolecules and glia support cells, and the contribution of the physical attributes of these components in maintenance and regulation of neuronal function...

Unconscious information changes decision accuracy [Psychological and Cognitive Sciences]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
The controversial idea that information can be processed and evaluated unconsciously to change behavior has had a particularly impactful history. Here, we extend a simple model of conscious decision-making to explain both conscious and unconscious accumulation of decisional evidence. Using a novel dichoptic suppression paradigm to titrate conscious and unconscious...

DLK1/PREF1 dosage regulates nutrient metabolism [Medical Sciences]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance and obesity, as well as progressive liver dysfunction. Recent animal studies have underscored the importance of hepatic growth hormone (GH) signaling in the development of NAFLD. The imprinted Delta-like homolog 1 (Dlk1)/preadipocyte factor 1 (Pref1) gene encodes a complex protein...

FGFR inhibitors to overcome resistance [Medical Sciences]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation. Resistance usually results from selection for mutant kinases that are impervious to the action of the drug or from up-regulation of compensatory signaling pathways. Preclinical studies have demonstrated that...

NUP62 depletion and chronic stress [Neuroscience]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Genetic evidence suggests cell-type–specific functions for certain nucleoporins, and gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the prefrontal cortex of major depressives. Chronic stress, which can precipitate depression, induces changes in the architecture and plasticity of apical dendrites that are particularly evident in the...

Heterogeneity of drug-resistance in cancer [Applied Mathematics]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Targeted therapies provide an exciting new approach to combat human cancer. The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the evolution of resistance have been implicated, including mutation of target genes and activation...

General mode of action of macrolide antibiotics [Biochemistry]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can differentially affect synthesis of individual proteins. To understand the general mechanism...

Location of PsbP and PsbQ in higher plant PS II [Plant Biology]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Protein cross-linking and radiolytic footprinting coupled with high-resolution mass spectrometry were used to examine the structure of PsbP and PsbQ when they are bound to Photosystem II. In its bound state, the N-terminal 15-amino-acid residue domain of PsbP, which is unresolved in current crystal structures, interacts with domains in the...

IP6K1 mediates CRL4-signalosome complex formation [Cell Biology]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Inositol polyphosphates containing an energetic pyrophosphate bond are formed primarily by a family of three inositol hexakisphosphate (IP6) kinases (IP6K1–3). The Cullin-RING ubiquitin ligases (CRLs) regulate diverse biological processes through substrate ubiquitylation. CRL4, comprising the scaffold Cullin 4A/B, the E2-interacting Roc1/2, and the adaptor protein damage-specific DNA-binding protein 1, is...
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