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Alex Epstein: ‘Defend the Right to Free Speech Against Climate Fascism’

Climate Depot - Fri, 06/24/2016 - 14:19
Via Alex Epstein’s email: Last week I wrote you about how the government’s persecution of companies and think-tanks who challenge climate catastrophism extended to me–and that I responded with a righteous three-word response to the Massachusetts Attorney General and a $100,000 challenge to the leader of the campaign, Al Gore, to debate me. The story has gotten [...]

Dose-dependent role of claudin-1 in AD [Medical Sciences]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. It was recently noted that the characteristics of epidermal barrier functions critically influence the pathological features of AD. Evidence suggests that claudin-1 (CLDN1), a major component of tight junctions (TJs) in the epidermis, plays a key role in human...

E-cadherin and hepatitis C virus [Commentaries]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Hepatitis C virus (HCV) is a major global cause of liver disease, including cirrhosis and hepatocellular carcinoma (HCC). Although direct-acting antivirals (DAAs) can cure the majority of infected patients, their high cost prevents access to treatment for the majority of patients worldwide. Moreover, not all patient groups respond to therapy...

Tracking heme dynamics [Commentaries]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Heme is an essential protein cofactor used by nearly all forms of life to perform a wide range of tasks, from shuttling electrons to keep photosynthesis running to moving the oxygen we breathe from our lungs throughout our bodies (1). Most of the heme in humans is produced in erythroid...

Strategies to treat fibrosis [Commentaries]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Fibroproliferative disorders are estimated to contribute to 45% of deaths in the United States (1). Although this huge number includes atherosclerosis, the biggest killer in the developed world, less common conditions, such as idiopathic pulmonary fibrosis, fibrosis of the liver and kidney, and systemic sclerosis are also associated with high...

Plants wait for the lights to change to red [Commentaries]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
If we want to grow vegetables in a garden, we pick a nice sunny spot and clear a space free from other plants that might shade them. Sunlight provides the energy for photosynthesis: the more light, the bigger they grow. But plants are not so simple; they never are. Growth...

Role reversal in Cheerios effect [Commentaries]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
The Cheerios effect (1) refers to the common observation that floating objects (say, little toruses of Cheerios cereal floating on water or milk) tend to agglomerate either with each other or to the wall that contains the liquid. Floating objects distort the liquid–vapor interface due to a combination of wetting...

ATP and exocytosis [Pharmacology]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
The colligative properties of ATP and catecholamines demonstrated in vitro are thought to be responsible for the extraordinary accumulation of solutes inside chromaffin cell secretory vesicles, although this has yet to be demonstrated in living cells. Because functional cells cannot be deprived of ATP, we have knocked down the expression...

PLC{beta}1 induces membrane tubulation [Cell Biology]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Lipid membrane curvature plays important roles in various physiological phenomena. Curvature-regulated dynamic membrane remodeling is achieved by the interaction between lipids and proteins. So far, several membrane sensing/sculpting proteins, such as Bin/amphiphysin/Rvs (BAR) proteins, are reported, but there remains the possibility of the existence of unidentified membrane-deforming proteins that have...

Structure of the human 26S proteasome [Biophysics and Computational Biology]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Protein degradation in eukaryotic cells is performed by the Ubiquitin-Proteasome System (UPS). The 26S proteasome holocomplex consists of a core particle (CP) that proteolytically degrades polyubiquitylated proteins, and a regulatory particle (RP) containing the AAA-ATPase module. This module controls access to the proteolytic chamber inside the CP and is surrounded...

Viral kinase mimics S6 kinase [Microbiology]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi’s sarcoma-associated...

Correction for Landhuis, Science and Culture: Putting a game face on biomedical research [Corrections]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
SCIENCE AND CULTURE Correction for “Science and Culture: Putting a game face on biomedical research,” by Esther Landhuis, which appeared in issue 24, June 14, 2016, of Proc Natl Acad Sci USA (113:6577–6578; 10.1073/pnas.1607585113). The editors note that on page 6577, left column, first paragraph, line 1, “In 2011” should...

NIR nanoparticles for imaging and siRNA delivery [Medical Sciences]

PNAS Early Edition Articles - Fri, 06/24/2016 - 12:38
Anaplastic thyroid cancer (ATC), one of the most aggressive solid tumors, is characterized by rapid tumor growth and severe metastasis to other organs. Owing to the lack of effective treatment options, ATC has a mortality rate of ∼100% and median survival of less than 5 months. RNAi nanotechnology represents a...

Material testing continues on French steam generators

World Nuclear News - Fri, 06/24/2016 - 09:17
Parts of some steam generators at 18 nuclear power units in France may have similar anomalies discovered in the steel of the pressure vessel of the Flamanville EPR, utility EDF has informed the French nuclear regulator.

Mexican dry storage facility nearing completion

World Nuclear News - Fri, 06/24/2016 - 09:08
An independent used fuel storage installation (ISFSFI) at Mexico's Laguna Verde nuclear power plant has been built in record time, with fuel loading into the facility's storage canisters expected to begin this month.

UN boss: Brexit may mean rewriting Paris Agreement on climate change

Climate Depot - Fri, 06/24/2016 - 08:07
A vote for Brexit in tomorrow’s UK referendum on EU membership (23 June) would mean that the COP21 agreement would have to be rewritten, the executive secretary of the UN Framework Convention on Climate Change said today (22 June) in Brussels. Christiana Figueres, one of the architects of the historic deal struck last December to [...]

‘At war with itself’: Obama Dept of Energy says Obama EPA climate rule to cost 400,000 jobs

Climate Depot - Fri, 06/24/2016 - 07:58
Testifying before Congress, EPA Administrator Gina McCarthy says that the Obama Department of Energy is wrong with its analysis that the Agency’s Clean Power Plan will “reduce economic growth, increase electricity costs, and result in almost 400,000 jobs lost over the next 15 years”. McCarthy: “That is exactly opposite of what we believe will happen [...]

Lies, Damned Lies, And The EPA’s ‘Clean Power Plan’

Climate Depot - Fri, 06/24/2016 - 07:53
President Obama’s “Clean Power Plan” is on pause, thanks to a Supreme Court ruling in March after more than two dozen states filed suit to stop it. A new report shows why the plan should be scrapped entirely, and the EPA sued for fraud. By its own admission, the EPA says Clean Power Plan is [...]

4,000 YEARS OF CLIMATE IN ONE CHART

Climate Depot - Fri, 06/24/2016 - 07:51
From Andy May at Watts Up With That, a fascinating chart that plots estimated global mean temperatures along with historical events over the last 4,000 years. Most of the time line is based on ice cores, while the most recent temperatures are from the HadCRUT (probably inflated) database. There are explanation and commentary at the [...]
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