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CD169+ macrophages directly prime CTLs [Immunology and Inflammation]

PNAS Early Edition Articles - Tue, 04/14/2015 - 10:03
Dendritic cells (DCs) are considered the most potent antigen-presenting cells (APCs), which directly prime or cross-prime MHC I-restricted cytotoxic T cells (CTLs). However, recent evidence suggests the existence of other, as-yet unidentified APCs also able to prime T cells. To identify those APCs, we used adenoviral (rAd) vectors, which do...

IRBIT regulates CaMKII{alpha} and catecholamine levels [Neuroscience]

PNAS Early Edition Articles - Tue, 04/14/2015 - 10:03
Inositol 1,4,5-trisphosphate receptor (IP3R) binding protein released with IP3 (IRBIT) contributes to various physiological events (electrolyte transport and fluid secretion, mRNA polyadenylation, and the maintenance of genomic integrity) through its interaction with multiple targets. However, little is known about the physiological role of IRBIT in the brain. Here we identified...

Court halts restart of Takahama reactors

World Nuclear News - Tue, 04/14/2015 - 08:48
The restart of units 3 and 4 of Kansai Electric Power Company's Takahama nuclear power plant, expected by the end of this year, has been blocked by a temporary injunction imposed by the Fukui District Court today. Kansai said it will appeal the ruling.

Economic cost of Japan's nuclear shutdown

World Nuclear News - Tue, 04/14/2015 - 08:42
Nuclear power benefitted the Japanese economy by some ¥33 trillion over the years, said Masakazu Toyoda of the Institute of Energy Economics, Japan (IEEJ), and the country risks wasting this in its slow progress to restart its reactors.

Skeptic win… American Physical Society removes ‘incontrovertible’ from climate change position

Climate Depot - Tue, 04/14/2015 - 08:07
Skeptic win… American Physical Society removes 'incontrovertible' from climate change position. via Climatewire pic.twitter.com/LHRMGz4Aaf — JunkScience.com (@JunkScience) April 14, 2015

Scrap fossil fuel subsidies now and bring in carbon tax, says World Bank chief

Climate Depot - Tue, 04/14/2015 - 06:38

Can a carbon tax save a meal? AGW induced warmer waters threaten future of traditional fish and chips

Climate Depot - Tue, 04/14/2015 - 06:33

How global warming HELPED man: Earliest humans migrated into Europe 1.4 million years ago thanks to rising temperatures

Climate Depot - Tue, 04/14/2015 - 06:29

Class-Action Lawsuit: ‘Global warming of more than 2C will lead to a violation of fundamental human rights’

Climate Depot - Tue, 04/14/2015 - 06:20

‘American People Aren’t Stupid Enough to Buy Climate Change Narrative’

Climate Depot - Tue, 04/14/2015 - 06:18

‘Good Science Prevails’: Renowned Scientist Dr. Fred Singer Talks Climate Change

Climate Depot - Tue, 04/14/2015 - 06:15

Morano evaluates Presidential field: Sen. Rubio ‘looks like a deer in the headlights when the media come after him’ on AGW

Climate Depot - Tue, 04/14/2015 - 06:08

Enviros Question Hillary’s Commitment To Fighting Global Warming

Climate Depot - Tue, 04/14/2015 - 06:03

‘Data Plainly Show No Correlation Between Atmospheric CO2 Concentrations And Global Sea Ice’

Climate Depot - Tue, 04/14/2015 - 05:56
Data Plainly Show No Correlation Between Atmospheric CO2 Concentrations And Global Sea Ice! http://notrickszone.com/2015/04/14/data-plainly-show-no-correlation-between-atmospheric-co2-concentrations-and-global-sea-ice/ The poles, we are told, are supposed to be the tell-tale barometer of global warming. No place is supposed to warm up as quickly as the poles. And because there are practically no thermometers to speak of at both the North [...]

Porvair's role in China’s small modular reactor development

World Nuclear News - Tue, 04/14/2015 - 05:29
Porvair Filtration Group has announced its role in the High Temperature Gas-Cooled Reactor currently being developed at Tsinghua University in China. The British company said the technology has the potential to create affordable and reliable energy in some of the world's poorest and most remote countries.

Monckton: ‘I challenge climate fascists with $500,000 bet’

Climate Depot - Mon, 04/13/2015 - 22:13

Hillary Clinton to make climate ‘top of agenda’ for White House run

Climate Depot - Mon, 04/13/2015 - 21:30

Fc conformation governs antiinflammatory response [Immunology and Inflammation]

PNAS Early Edition Articles - Mon, 04/13/2015 - 13:09
The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors. Sialylated...

Cities, traffic and CO2 [Sustainability Science]

PNAS Early Edition Articles - Mon, 04/13/2015 - 13:09
Emissions of CO2 from road vehicles were 1.57 billion metric tons in 2012, accounting for 28% of US fossil fuel CO2 emissions, but the spatial distributions of these emissions are highly uncertain. We develop a new emissions inventory, the Database of Road Transportation Emissions (DARTE), which estimates CO2 emitted by...
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