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COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells [Immunology and Inflammation]

PNAS Early Edition Articles - Tue, 01/17/2017 - 14:06
In recent years, it has been established that programmed cell death protein ligand 1 (PD-L1)–mediated inhibition of activated PD-1+ T lymphocytes plays a major role in tumor escape from immune system during cancer progression. Lately, the anti–PD-L1 and –PD-1 immune therapies have become an important tool for treatment of advanced...

GOP environment chairman plans ‘wholesale change’ at EPA

Climate Depot - Tue, 01/17/2017 - 12:34
The top senator overseeing the Environmental Protection Agency (EPA) is planning a “wholesale change” at the agency under President-elect Donald Trump and a Republican Congress. Sen. John Barrasso (R-Wyo.), the new chairman of the Environment and Public Works Committee, wrote in a Fox News opinion piece Tuesday that he and Trump EPA nominee Scott Pruitt [...]

Statistician: UN climate treaty will cost $100 trillion – To Have No Impact – Postpone warming by less than four years by 2100

Climate Depot - Tue, 01/17/2017 - 11:21
Danish statistician Dr. Bjorn Lomborg, the President of the Copenhagen Consensus Center, has come out denouncing the UN climate Paris agreement as a massive waste of money that will do nothing to impact climate change. In a January 16, 2017 Prager U video titled, “The Paris Climate Agreement Won’t Change the Climate,” Lomborg explains that “the agreement will [...]

Environmental approval for Yeelirrie

World Nuclear News - Tue, 01/17/2017 - 09:44
The government of Western Australia yesterday granted environmental approval to Cameco Australia's proposed Yeelirrie uranium project, subject to conditions that include measures to mitigate risks to underground fauna.

Geologist: ‘The delusional war on warmth’

Climate Depot - Tue, 01/17/2017 - 09:26
By Viv Forbes For decades, global warming scaremongers have been stealing energy from the environment using windmills, solar collectors, and biofuels, force-fed by carbon taxes and emission trading schemes.  Their delusional dream is to cool the globe. However, there has been no global warming for nearly 20 years.  Right now, the great ice sheets are [...]

Earth Hour in 3D: Dim, Dark and Dopey

Climate Depot - Tue, 01/17/2017 - 07:39
World Wide Fund for Nature (Australia) is gearing up for its tenth idiotic Earth Hour at 8.30pm on Saturday, March 25. Once again it will be urging people to turn off lights  (but not fridges, freezers, TVs, dishwashers, computers, aircons and smart-phones). If WWF is aware that satellite data shows no atmospheric warming for the [...]

Trump’s mission: ‘Bolster America’s energy sector to unleash the U.S. economy’

Climate Depot - Mon, 01/16/2017 - 23:02
As Trump takes on that goal, he should keep four main tenets in mind: respect for private property rights, reliance on voluntary exchange, tax neutrality, and consumer welfare. The Trump administration will have to undo eight years of obstruction under President Barack Obama’s relentless public policy war against fossil fuels. After a good many executive [...]

UK Guardian: ‘The last five years have not been great at Greenpeace’ – ‘Are they losing their nerve?’

Climate Depot - Mon, 01/16/2017 - 22:59
Dawn was breaking when the campaigners used slingshots to fire ropes on to the rig. But as they began to scale the Prirazlomnaya, aiming to unfurl a banner denouncing Russia’s attempts to drill for oil in the Arctic, their hopes of another successful Greenpeace “action” swiftly faded. They had been anticipating high-pressure hoses that sprayed [...]

Canada’s carbon-tax rebellion! ‘How is it justified for you to ask me to pay a carbon tax?’

Climate Depot - Mon, 01/16/2017 - 20:23
After the audience broke out into 10 seconds of applause and shouts of support for the woman, Trudeau bobbed and weaved, riding the technicality that electricity is a local matter and that, in fact, it was the government of Liberal Premier Kathleen Wynne that was responsible for Ontario’s soaring hydro bills, the product of the [...]

NPR: Ice Shelf Is Cracking In Antarctica- But ‘it’s probably just simply a natural event…not directly attributable to any warming’

Climate Depot - Mon, 01/16/2017 - 13:29
But this is not just another sad climate change story. It’s more complicated. “A lot of things are going on deep inside the ice,” says Adrian Luckman, a glaciologist at Swansea University in the U.K. He’s also leading a project to track changes in the ice shelf. Luckman says climate change is certainly influencing this [...]

‘Reaction To Trump’s Team Proves Climate Alarmists Are The Real Deniers’

Climate Depot - Mon, 01/16/2017 - 12:39
After the election, there were reports of EPA employees breaking down in tears and Energy Department staffers needing counseling. It’s not because they care about the environment. By Julie Kelly JANUARY 9, 2017 Today is the Day Against Denial, where climate change activists around the country are protesting President-elect Donald Trump’s cabinet picks. Activists will [...]

EDF gets approval to restart nine units

World Nuclear News - Mon, 01/16/2017 - 10:49
France's nuclear regulator, the Autorité de Sûreté Nucléaire, has approved the restart of nine of the 12 reactors affected by the carbon concentration anomaly in the steam generator channel heads manufactured by Japan Casting and Forging Corporation. The approval, which followed ASN's examination of the results of inspections and technical demonstrations provided by EDF for the 900 MWe reactors, was announced on 12 January.

Review begins for first US SMR site

World Nuclear News - Mon, 01/16/2017 - 10:42
The Tennessee Valley Authority has welcomed the acceptance for regulatory review of its early site permit application for the Clinch River site in Tennessee as a milestone towards the potential use of small modular reactors in its operating fleet.

NRG completes irradiation creep program for EDF Energy

World Nuclear News - Mon, 01/16/2017 - 09:57
The Nuclear Research and Consultancy Group (NRG) has announced the successful completion of a program for EDF Energy to study the effects of irradiation creep on graphite. Over a period of four years, four consecutive irradiation stages were performed on loaded graphite specimens in the High Flux Reactor in Petten, the Netherlands.

Russia announces cancellation of Khmelnitsky agreement

World Nuclear News - Mon, 01/16/2017 - 08:55
The Russian government has confirmed that its 2010 agreement with Ukraine on building a third and fourth reactor at the Khmelnitsky nuclear power plant has been cancelled. According to a statement posted on the Russian Foreign Ministry's website for legal information on 13 January, the intergovernmental agreement was terminated on 12 May last year.

Bye, Bye Holdren, Hello Happer!? Trump May Pick Prominent Climate Skeptic As His Science Czar

Climate Depot - Mon, 01/16/2017 - 08:46
President-elect Donald Trump met with a Princeton University physicist and skeptic of man-made global warming who observers believe could be the next White House science czar. Trump met with Dr. Will Happer in New York City Friday. Happer didn’t take any questions entering or leaving Trump Tower last week, so it’s hard to say what [...]

Study: ‘Strong evidence that first half of 20th century had more extreme weather than the second half’

Climate Depot - Mon, 01/16/2017 - 08:36
Abstract:  It is widely promulgated and believed that human-caused global warming comes with increases in both the intensity and frequency of extreme weather events. A survey of official weather sites and the scientific literature provides strong evidence that the first half of the 20th century had more extreme weather than the second half, when anthropogenic global [...]

Large stationary gravity wave in the atmosphere of Venus

Nature Geoscience Advanced Online - Mon, 01/16/2017 - 00:00

Nature Geoscience. doi:10.1038/ngeo2873

Authors: Tetsuya Fukuhara, Masahiko Futaguchi, George L. Hashimoto, Takeshi Horinouchi, Takeshi Imamura, Naomoto Iwagaimi, Toru Kouyama, Shin-ya Murakami, Masato Nakamura, Kazunori Ogohara, Mitsuteru Sato, Takao M. Sato, Makoto Suzuki, Makoto Taguchi, Seiko Takagi, Munetaka Ueno, Shigeto Watanabe, Manabu Yamada & Atsushi Yamazaki

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